(±)-Bay K8644

>99% (HPLC)

L-type Ca2+ channels

Synthetic

(±)-Bay K8644 (#B-350) is a highly pure, synthetic, and biologically active compound.

356.3

(±)-Bay K8644 is a dihydropyridine that acts as an L-type, voltage-gated Ca2+ channel agonist. The (-)-enantiomer has strong Ca2+ channel agonist properties, whereas the (+)-enantiomer has weak Ca2+ channel antagonist activity. The net activity of the racemic mix is L-type channel opening. In the presence of this agonist, channels tend to open for longer periods causing a large increase in the channel microscopic response1-4. (±)-Bay K8644 is also an inhibitor (by increasing the inactivation) of a Shaker KV channel5.

Ethanol, methanol or DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

1-5 μM.

Lyophilized

C16H15F3N2O4.

71145-03-4, 93468-89-4

Up to four weeks at 4°C or three months at -20°C.